Differential regulation of genomic imprinting by TET proteins in embryonic stem cells
作者： Lizhi Liu , Shi-Qing Mao , Chelsea Ray , Yu Zhang , Fong T. Bell
DOI: 10.1016/J.SCR.2015.08.010
关键词:
摘要: TET proteins have been found to play an important role in active demethylation at CpG sites mammals. There are some reports implicating their functions removal of DNA methylation imprint the imprinted regions germline. However, it is not well established whether can also be involved embryonic stem (ES) cells. Here we report that loss caused a significant increase Igf2-H19 region ES We observed variable Peg1 clones devoid proteins, particular differentiated By contrast, did observe Peg3, Snrpn and Dlk1-Dio3 cells lacking proteins. Interestingly, result embryoid bodies (EB). Therefore, seem differentially maintaining subset EBs.
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