摘要: Gene and chromosome changes in breast cancer have been analysed using molecular cytological methods. No single gene alterations are frequent cancer, but several detected, line with multigenetic disease, although malignant progression relation to is poorly documented. The most common tumour suppressor mutations, detected about ¼ of tumours the TP53 gene, that encodes a transcription factor. Mutations other CDH1 encoding E-cadherin adhesion protein, CHK2 cell cycle checkpoint kinase, BRCA1 BRCA2 genes, DNA repair proteins FHIT, diadenosine hydrolase, will be reviewed. mechanism behind frequently instability genome cells understood, some studies associated it mutations TP53, or genes.
sci-hub.st 参考文章(72)
Jacob Falck, Niels Mailand, Randi G. Syljuåsen, Jiri Bartek, Jiri Lukas, The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. ,vol. 410, pp. 842- 847 ,(2001) , 10.1038/35071124
Roberta Melchionna, Xiao-Bo Chen, Alessandra Blasina, Clare H. McGowan, Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nature Cell Biology. ,vol. 2, pp. 762- 765 ,(2000) , 10.1038/35036406
Bjarnveig I. Sigbjörnsdóttir, Rósa Björk Barkardóttir, Bjarni A. Agnarsson, Valgarður Egilsson, Júlíus Guðmundsson, Gísli Ragnarsson, Jón Gunnlaugur Jónasson, Ella Kristín Geirsdóttir, Guðrún Jóhannesdóttir, Ásgeir Sigurðsson, Guðný Eiríksdóttir, Sigurður Ingvarsson, High incidence of loss of heterozygosity in breast tumors from carriers of the 999del5 BRCA2 mutation ,(2015)
Sigbjornsdottir Bi, Agnarsson Ba, Huiping C, Jonasson Jg, Ingvarsson S, Alterations of the FHIT gene in breast cancer: association with tumor progression and patient survival. Cancer Detection and Prevention. ,vol. 25, pp. 292- ,(2001)
Torben A. Kruse, Mette Yilmaz, Jens Overgaard, Lise Lotte Hansen, Jørn Andersen, Allelic loss of 16q23.2-24.2 is an independent marker of good prognosis in primary breast cancer Cancer Research. ,vol. 58, pp. 2166- 2169 ,(1998)
William B. Isaacs, Stephen B. Baylin, Nancy E. Davidson, Jeremy R. Graff, James G. Herman, Rena G. Lapidus, Paula M. Pitha, Rosa Xu, Hemi Chopra, David F. Jarrard, E-Cadherin Expression Is Silenced by DNA Hypermethylation in Human Breast and Prostate Carcinomas Cancer Research. ,vol. 55, pp. 5195- 5199 ,(1995)
Rosa Björk Barkardottir, Adalgeir Arason, Valgardur Egilsson, Gudrun Johannesdottir, Julius Gudmundsson, Jon Thor Bergthorsson, Sigurdur Ingvarsson, Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13. Cancer Research. ,vol. 55, pp. 4830- 4832 ,(1995)
Sigurdur Ingvarsson, Bjarnveig I Sigbjornsdottir, Chen Huiping, Sigridur H Hafsteinsdottir, Gisli Ragnarsson, Rosa B Barkardottir, Adalgeir Arason, Valgardur Egilsson, Jon TH Bergthorsson, Mutation analysis of the CHK2 gene in breast carcinoma and other cancers Breast Cancer Research. ,vol. 4, pp. 1- 6 ,(2002) , 10.1186/BCR435
Barkardottir Rb, Gudmundsson J, Jonasson Jg, Eiriksdottir G, Ingvarsson S, Ragnarsson G, Sigurdsson A, Kristjansson Ak, Egilsson, Loss of heterozygosity at chromosome 7q in human breast cancer: association with clinical variables. Anticancer Research. ,vol. 17, pp. 93- 98 ,(1997)
G. Berx, A. M. Cleton-Jansen, F. Nollet, W. J. de Leeuw, M. van de Vijver, C. Cornelisse, F. van Roy, E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. The EMBO Journal. ,vol. 14, pp. 6107- 6115 ,(1995) , 10.1002/J.1460-2075.1995.TB00301.X