The metabolism of atypical antipsychotic drugs: an update.

摘要: This paper reviews the current literature describing metabolism of both multi-receptor clozapine analogue atypical antipsychotic drugs (clozapine, olanzapine, and quetiapine) serotonin-dopamine antagonist (risperidone, sertindole ziprasidone), to highlight significance those data in context clinical practice. The former group shares a similar tricyclic structural nucleus are metabolized through three major categorical metabolic pathways—N+-oxidation, N-glucuronidation, phases 1 2 biotransformation with final glucuronidation before renal excretion. Differing quetiapine has incomplete its metabolism. latter diversified chemical structures absence on N+-oxidation N-glucuronidation literature. But their routes phase versatile although far from completion. No apparent significant drug interactions practice reported, QT prolongation is implicated all drugs. None six identified as inhibitors or inducers any co-administered medication. author suggests need for more research address some pertinent issues