Nicotinamide is a brain constituent with benzodiazepine-like actions.
作者： H. MÖHLER , P. POLC , R. CUMIN , L. PIERI , R. KETTLER
DOI: 10.1038/278563A0
关键词:
摘要: BENZODIAZEPINES are a group of drugs with wide therapeutic application as anxiolytics, hypnotics, anticonvulsants and muscle relaxants. To exert their pharmacological effects, they apparently interact brain-specific benzodiazepine receptor characterised by high-affinity binding site for this compounds1,2. In analogy to the identification morphine receptors in brain subsequent isolation opioid peptides, discovery prompted search an endogenous constituent, which physiologically may display benzodiazepine-like actions3. We describe here actions nicotinamide, compound might these physiologically.
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sci-hub.se 参考文章(18)
R. Tissot, THE EFFECTS OF CERTAIN DRUGS ON THE SLEEP CYCLE IN MAN. Progress in Brain Research. ,vol. 18, pp. 175- 177 ,(1965) , 10.1016/S0079-6123(08)63593-1
RICHARD F. SQUIRES, CLAUS BRAESTRUP, Benzodiazepine receptors in rat brain Nature. ,vol. 266, pp. 732- 734 ,(1977) , 10.1038/266732A0
Takeo Deguchi, Arata Ichiyama, Yasutomi Nishisuka, Osamu Hayaishi, Studies on the biosynthesis of nicotinamide-adenine dinucleotide in the brain Biochimica et Biophysica Acta (BBA) - General Subjects. ,vol. 158, pp. 382- 393 ,(1968) , 10.1016/0304-4165(68)90292-4
Burkhard Scherer, Wolf Krämer, Influence of niacinamide administration on brain 5-HT and a possible mode of action Life Sciences. ,vol. 11, pp. 189- 195 ,(1972) , 10.1016/0024-3205(72)90260-3
Leslie L. Iversen, GABA and benzodiazepine receptors. Nature. ,vol. 275, pp. 477- 477 ,(1978) , 10.1038/275477A0
P. Polc, H. M�hler, W. Haefely, The effect of diazepam on spinal cord activities: Possible sites and mechanisms of action Naunyn-Schmiedeberg's Archives of Pharmacology. ,vol. 284, pp. 319- 337 ,(1974) , 10.1007/BF00504702
J. M. Beaton, G. V. Pegram, J. R. Smythies, R. J. Bradley, The effects of nicotinamide on mouse sleep Experientia. ,vol. 30, pp. 926- 927 ,(1974) , 10.1007/BF01938366
H. Mohler, T. Okada, Benzodiazepine receptor: demonstration in the central nervous system Science. ,vol. 198, pp. 849- 851 ,(1977) , 10.1126/SCIENCE.918669
J. M. Beaton, The sedative effects of nicotinamide on gerbil wheel-running activity. Cellular and Molecular Life Sciences. ,vol. 32, pp. 1036- 1037 ,(1976) , 10.1007/BF01933957
D.R. Curtis, D. Lodge, G.A.R. Johnston, S.J. Brand, Central actions of benzodiazepines. Brain Research. ,vol. 118, pp. 344- 347 ,(1976) , 10.1016/0006-8993(76)90723-X