Recent advances in corneal stromal dystrophies.

摘要: Newer biochemical, immunohistochemical, and cell culture techniques have been used to investigate metabolic abnormalities in corneal stromal dystrophies. Organ cultures of macular dystrophy (MCD) shown a defect the synthesis keratan sulphate proteoglycan. Alterations glycoconjugates also detected using biotinylated lectins. An absence normal proteoglycan has blood patients with MCD. Granular (GCD) is associated increased phospholipid, as by biochemical analysis staining Luxol-fast blue. Immunohistochemical stains revealed reactivity antibodies against microfibrillar protein at edges deposits. Clinically, recently described early features lattice (LCD) include discrete ovoid subepithelial opacities, diffuse central anterior haze, dots filamentary lines. Early clinical recognition these genetic disorders, appropriate studies define their nature possible pathogenetic mechanisms, are important expanding our knowledge this disease spectrum.