Prostaglandins as reducing agents: a model of adenylate cyclase activation?
作者： D.A. Peterson , B. Kelly , N. Mehta , J.M. Gerrard
DOI: 10.1016/0090-6980(88)90012-3
关键词:
摘要: It has been suggested that adenylate cyclase activation involves reduction of a disulfide linkage. Prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), I2 (PGI2) and F2 alpha (PGF2 alpha) were tested for their ability to act as reducing agents with either cytochrome c, or the 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), latter catalytic amount ferric chloride. PGE1, PGE2, PGI2 significantly reduced c while PGF2 did not. PGE2 DTNB The results are consistent postulate prostaglandins which effective in activating can might be involved reductive cyclase.
elsevier.com
sci-hub.se 参考文章(13)
E. Remold-O'Donnell, Stimulation and desensitization of macrophage adenylate cyclase by prostaglandins and catecholamines. Journal of Biological Chemistry. ,vol. 249, pp. 3615- 3621 ,(1974) , 10.1016/S0021-9258(19)42618-5
Gerd Till, Ludwig Steggemann, Jörg Menzel, Diethard Gemsa, Release of Cyclic AMP from Macrophages by Stimulation with Prostaglandins Journal of Immunology. ,vol. 114, pp. 1422- 1424 ,(1975)
Henry R. Bourne, Lawrence M. Lichtenstein, Kenneth L. Melmon, Pharmacologic control of allergic histamine release in vitro: evidence for an inhibitory role of 3',5'-adenosine monophosphate in human leukocytes. Journal of Immunology. ,vol. 108, pp. 695- 705 ,(1972)
Sidney M. Wolfe, N.Raphael Shulman, Adenyl cyclase activity in human platelets Biochemical and Biophysical Research Communications. ,vol. 35, pp. 265- 272 ,(1969) , 10.1016/0006-291X(69)90277-0
D. Peterson, J. Gerrard, S. Glover, G. Rao, J. White, Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus. Science. ,vol. 215, pp. 71- 73 ,(1982) , 10.1126/SCIENCE.6274020
R. Schultz, N. Pavlidis, W. Stylos, M. Chirigos, Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series. Science. ,vol. 202, pp. 320- 321 ,(1978) , 10.1126/SCIENCE.694537
Steven M. Taffet, Thomas E. Eurell, Stephen W. Russell, Regulations of macrophage-mediated tumor cell killing by prostaglandins: Comparison of the effects of PGE2 and PGI2 Prostaglandins. ,vol. 24, pp. 763- 774 ,(1982) , 10.1016/0090-6980(82)90057-0
D.A. Peterson, J.M. Gerrard, G.H.R. Rao, J.G. White, Epinephrine and other activators of prostaglandin endoperoxide synthetase can reduce Fe3+-heme to Fe2+-heme Prostaglandins and Medicine. ,vol. 5, pp. 357- 364 ,(1980) , 10.1016/0161-4630(80)90107-X
J.E. Tateson, S. Moncada, J.R. Vane, Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets Prostaglandins. ,vol. 13, pp. 389- 397 ,(1977) , 10.1016/0090-6980(77)90019-3
Asru K. SINHA, Robert W. COLMAN, Inhibition of ADP-induced platelet aggregation by reduced factor Xa FEBS Journal. ,vol. 136, pp. 57- 62 ,(1983) , 10.1111/J.1432-1033.1983.TB07704.X