Long-term effects of fish oil on lipoprotein subfractions and low density lipoprotein size in non-insulin-dependent diabetic patients with hypertriglyceridemia

摘要: The effects of fish oil on lipoprotein subfractions and low density (LDL) size in non-insulin-dependent diabetes mellitus (NIDDM) patients with hypertriglyceridemia are unknown. To elucidate this, 16 NIDDM hypertriglyceridemic (plasma triglyceride 2.25‐5.65 mmol:l, plasma cholesterol 5 7.75 mmol:l) were randomly assigned to a 6-month period either moderate amounts (n8) or placebo (n 8) after 4 weeks wash-out 3 run-in. Diet hypoglycemic treatment unchanged throughout the experiment. LDL evaluated at baseline 6 months. Three VLDL measured end two periods. total lipid concentration all very (VLDL) was lower compared (large 124.3919.7 mg:dl vs 156.7945.5 mg:dl; intermediate 88.59 9.5 113.99 23.2 small 105.999.7 128.9940.7 mg:dl) (mean9SEM), although difference not statistically significant. Moreover, treatments, percentage distribution similar 37.59 3.3% 37.69 2.6%, 27.690.9% 31.092.4%; 34.993.7% 31.492.1%). Concerning LDL, no significant change observed treatments (255.492.2 A, 254.291.7 , oil; 253.79 2.0 253.39 1.7 placebo). subfraction also 1793% 1792%; 629 3% 659 3%; 219 189 2%), periods, confirming lack size. In conclusion, our study indicates that hypertriglyceridemia, does induce any improvement despite its positive triglycerides. © 1999 Elsevier Science Ireland Ltd. All rights reserved.