Bone turnover markers are associated with the PTH levels in different subtypes of pseudohypoparathyroidism type 1 patients.

摘要: OBJECTIVE Bone responsiveness to parathyroid hormone (PTH) in different subtypes of pseudohypoparathyroidism type 1 (PHP1) remains controversial. We aimed investigate this phenomenon using bone turnover markers (BTMs) a large cohort PHP1 patients. DESIGN Retrospective study. PATIENTS Sixty-three patients diagnosed by molecular analysis were used as subjects, and 48 sex- age-matched with nonsurgical hypoparathyroidism (NS-HP) for comparison. MEASUREMENTS markers, alkaline phosphatase (ALP), C-terminal telopeptide I collagen (β-CTX) related parameters compared among NS-HP. RESULTS Among all the (15 PHP1A, 14 familial 1B 34 sporadic 1B), 23.8% had elevated baseline BTM levels. No significant difference was found β-CTX levels subtypes. The level positively correlated PTH PHP1, PHP1B PHP1A (B = 0.001, 0.001 0.004, respectively; p < .05). significantly higher than those NS-HP (β-CTX: 0.56 ng/ml vs. 0.20 ng/ml, p = .001; ALP: 105 U/L 72 U/L, p = .001). serum adults. 22 followed up patients, changes BTMs associated r = .507, p = .023; r = .475, p = .034). CONCLUSIONS tissues respond subtypes, it is reasonable monitor normalize addition urinary calcium follow-up