Drug-use pattern, comorbid psychosis and mortality in people with a history of opioid addiction.

摘要: Opioid addiction is associated with high morbidityand increased risk of premature death (1, 2).Predictors mortality include malegender and older age (3), degree disability,length drug use heavy alcohol (4, 5).Comorbidity psychotic psychopathology isalso likely to be mortalityin people a history opioid addiction.Long-term abstinence from isassociated less morbidity better socialadjustment (5). The istherefore probably somewhat lower in whoabandon than continued orintermittent use. In the ALIVE study, acohort 1339 injection users Baltimorewere followed for mean 7.8 years thegroup that had ceased lowermortality group persistent injectors(20.1% vs. 42.5%) (6). authors point out thatthe sample was recruited predominantly (85%)through street referrals there highprevalence HIV almost allSorensen HJ, Jepsen PW, Haastrup S, Juel K. Drug-use pattern,comorbid psychosis opioidaddiction.ActaPsychiatrScand2005:111:244–249. BlackwellMunksgaard2004.Objective: To compare 15-year historyof dependence achieved stable abstinence, themortality Another objective tostudy influence hospitalization comorbid on the15-year mortality.Method: 1984, 188 persons (122 men 66 women) intravenous narcotics were interviewed about their drug-use pattern. A registry-based follow-up through 1999 andmortality assessed. Three 1984-drug-use categories formed.In category 1, cohort members fromdrug by 1984. Using Cox multiple regression analysis, we (i)estimated reduced 1 users, (ii) studiedthe mortality.Results: About 32% died during follow-up. The15-year by56% when compared perceived worst pattern.Hospitalization not independentlyassociated this sample. When categorieswere expectations general population,the standard rates (SMRs) clearly elevated. Even thestably abstinent (category 1), SMR significantlyelevated at least seven-fold both genders.Conclusion: People who injectingnarcotics withcontinued residual observed excess whohad apparently consistentwith view as chronic disease.