Regulatory T cells in tumor immunity

摘要: Recent studies have revealed that Foxp3(+)CD25(+)CD4(+) regulatory T cells (Tregs), which are physiologically engaged in the maintenance of immunological self-tolerance, play critical roles for control antitumor immune responses. For example, a large number Foxp3(+)Tregs infiltrate into tumors, and systemic removal enhances natural as well vaccine-induced T-cell Tregs recruited to tumor tissues via chemokines, such CCL22 binding CCR4 expressed by Tregs. They appear expand become activated draining lymph nodes recognizing tumor-associated antigens normal self-antigen cells. These results indicate cancer vaccines targeting self-antigens may potentially expand/activate hamper effective responses, immunity can therefore be enhanced depleting Tregs, attenuating Treg suppressive function, or rendering effector refractory Treg-mediated suppression. attempts indeed demonstrated combinations monoclonal antibodies capable modulating functions synergistically enhance activity more than single antibody therapy. Combination therapy variety molecules antigen-presenting cells, is envisaged promising anticancer immunotherapy.