Effects of (+-)3,4-methylenedioxymethamphetamine (MDMA) on brain dopaminergic activity in rats.

摘要: Abstract Acute treatment with (±)3,4-methylenedioxymethamphetamine (MDMA) at high doses (10 and 30 mg/kg, IP), but not lower increased locomotor activity in male rats. MDMA did consistently produce any other stereotyped behaviors dose. Dopamine (DA) turnover rate as estimated by the ratio of brain tissue levels 3,4-dihydroxyphenylacetic acid (DOPAC) over DA was decreased striatum for up to two hours after acute 10 mg/kg MDMA. inconsistently olfactory tubercle medial basal hypothalamus, unchanged prefrontal cortex substantia nigra/ventral tegmental area. Two a injection MDMA, all areas tested. d-amphetamine partially reversed haloperidol-induced elevation striatal DOPAC levels. In contrast, nonamphetamine stimulant, amfonelic acid, enhanced haloperidol's effect. chloral hydrate-anesthesized rats, injected IV inhibited spontaneous firing neurons nigra (34% decrease 4 MDMA). Seventeen days subchronic or 20 IP, twice per day four days), were unchaged tested compared control It is concluded that low has weak amphetamine-like effect on nigrostriatal well mesolimbic/mesocortical tuberoinfundibular Repeated does appear be toxic mesotelencephalic neurons.