The effect of mirtazapine augmentation of clozapine in the treatment of negative symptoms of schizophrenia: a double-blind, placebo-controlled study.
作者： Rocco Zoccali , Maria Rosaria Muscatello , Clemente Cedro , Pietro Neri , Diletta La Torre
DOI: 10.1097/00004850-200403000-00003
关键词:
摘要: The development of therapeutic strategies to effectively treat negative symptoms remains one the primary goals in treatment schizophrenia. Mirtazapine is first a new class dual action compounds, noradrenergic and specific serotonergic antidepressants (NaSSa), whose activity i
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lww.com 参考文章(48)
Lotta Arborelius, George G. Nomikos, Peter Hertel, Peter Salmi, Pernilla Grillner, Berit Backlund H��k, Uli Hacksell, Torgny H. Svensson, The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 353, pp. 630- 640 ,(1996) , 10.1007/BF00167182
Th. De Boer, G. S. F. Ruigt, H. H. G. Berendsen, The α2-selective adrenoceptor antagonist org 3770 (mirtazapine, Remeron®) enhances noradrenergic and serotonergic transmission Human Psychopharmacology-clinical and Experimental. ,vol. 10, ,(1995) , 10.1002/HUP.470100805
Edoardo Spina, Angela Avenosoa, Gabrielia Facciolà, Michele Fabrazzo, Palmiero Monteleone, Mario Maj, Emilio Perucca, Achille R Caputi, Effect of Fluoxetine on the Plasma Concentrations of Clozapine and Its Major Metabolites in Patients With Schizophrenia International Clinical Psychopharmacology. ,vol. 13, pp. 141- 145 ,(1998) , 10.1097/00004850-199805000-00009
A. Eden Evins, Donald C. Goff, Adjunctive Antidepressant Drug Therapies in the Treatment of Negative Symptoms of Schizophrenia CNS Drugs. ,vol. 6, pp. 130- 147 ,(1996) , 10.2165/00023210-199606020-00005
Leonard T. Meltzer, Kevin A. Serpa, Walter H. Moos, Evaluation in rats of the somnogenic, pyrogenic, and central nervous system depressant effects of muramyl dipeptide Psychopharmacology. ,vol. 99, pp. 103- 108 ,(1989) , 10.1007/BF00634462
John E. Overall, Donald R. Gorham, The Brief Psychiatric Rating Scale Psychological Reports. ,vol. 10, pp. 799- 812 ,(1962) , 10.2466/PR0.1962.10.3.799
Bryan K. Yamamoto, Susan Novotney, Regulation of Extracellular Dopamine by the Norepinephrine Transporter Journal of Neurochemistry. ,vol. 71, pp. 274- 280 ,(2002) , 10.1046/J.1471-4159.1998.71010274.X
H Meltzer, The role of serotonin in antipsychotic drug action Neuropsychopharmacology. ,vol. 21, pp. 106- 115 ,(1999) , 10.1016/S0893-133X(99)00046-9
Paul J. Gresch, Alan F. Sved, Michael J. Zigmond, Janet M. Finlay, Local Influence of Endogenous Norepinephrine on Extracellular Dopamine in Rat Medial Prefrontal Cortex Journal of Neurochemistry. ,vol. 65, pp. 111- 116 ,(2002) , 10.1046/J.1471-4159.1995.65010111.X
Haranath Parepally, K. N. Roy Chengappa, Rohan Ganguli, Jaspreet S. Brar, Sapna A. Sheth, Suzanne B. Kreinbrook, Alan R. Sandman, The Effects of Clozapine on Negative Symptoms in Patients with Schizophrenia with Minimal Positive Symptoms Annals of Clinical Psychiatry. ,vol. 9, pp. 227- 234 ,(1997) , 10.1023/A:1022352326334