The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes
作者： Kira V. Derkach , Vera M. Bondareva , Oxana V. Chistyakova , Lev M. Berstein , Alexander O. Shpakov
DOI: 10.1155/2015/245459
关键词:
摘要: In the last years treatment of type 2 diabetes mellitus (DM2) was carried out using regulators brain signaling systems. DM2 level serotonin is reduced. So far, effect increase on DM2-induced metabolic and hormonal abnormalities has been studied scarcely. The present work undertaken with aim filling this gap. induced in male rats by 150-day high-fat diet low dose streptozotocin (25 mg/kg) 70th day experiment. From 90th day, diabetic received for two months intranasal (IS) at a daily 20 g/rat. IS decreased body weight, improved glucose tolerance, insulin-induced utilization, lipid metabolism. Besides, it restored regulation adenylyl cyclase (AC) activity hypothalamus normalized AC stimulation β-adrenergic agonists myocardium. nondiabetic same alterations, some which were similar to those but expressed lesser extent. conclusion, elevation may be regarded as an effective approach treat its complications.
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