Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases.

摘要: D3 receptors represent a major focus of current drug design and development therapeutics for dopamine-related pathological states. Their close homology with the D2 receptor subtype makes selective antagonists challenging task. In this review, we explore relevance therapeutic utility or partial agonists endowed multireceptor affinity profile in field central nervous system disorders such as schizophrenia abuse. fact, peculiar distribution low brain abundance make them valuable target drugs devoid motor side effects classically elicited by antagonists. Recent research efforts were devoted to conception chemical templates possibly multi-target profile, especially regards other G-protein-coupled (GPCRs). A comprehensive overview recent literature is herein provided. particular, evolution has been tracked, according growing advancements both structural information refinement key pharmacophoric elements. The receptor/multireceptor functional profiles examined compounds covered, together their most significant pharmacological applications.