Airway responses towards allergens – from the airway epithelium to T cells

作者: D. Papazian , S. Hansen , P. A. Würtzen

DOI: 10.1111/CEA.12451

关键词:

摘要: Summary The prevalence of allergic diseases such as rhinitis is increasing, affecting up to 30% the human population worldwide. Allergic sensitization arises from complex interactions between environmental exposures and genetic susceptibility, resulting in inflammatory T helper 2 (Th2) cell-derived immune responses towards allergens. Emerging evidence now suggests that an epithelial dysfunction, coupled with inherent properties allergens, can be responsible for Several epithelial-derived cytokines, thymic stromal lymphopoietin (TSLP), IL-25 IL-33, influence tissue-resident dendritic cells (DCs) well Th2 effector cells. Exposure allergens does not elicit or any clinical symptoms nonatopic individuals, recent findings suggest a nondamaged, healthy epithelium lowers DCs' ability induce T-cell The purpose this review was summarize current knowledge on which signals airway epithelium, first contact inhaled all way ensuing Th2-cell responses, pathology diseases.

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