Characterization of thymus atrophy in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus
作者： Yuli He , Gang Wang , Yonggang Liu , Wenda Shi , Zifeng Han
DOI: 10.1016/J.VETMIC.2012.05.040
关键词:
摘要: Our previous study has demonstrated that piglets infected with highly pathogenic PRRSV (HP-PRRSV) induced significant thymus atrophy. The aim of this was to further investigate the lesions in HP-PRRSV or and changes thymic T cell populations. were evaluated for thymus/body weight ratios, pathological virus load thymus, apoptosis ultrastructure thymocytes. result showed ratios HP-PRRSV-infected significantly reduced compared PRRSV-infected control piglets, characterized by severe cortical depletion number thymocytes undergoing increased approximately forty-fold than on 7 days post-inoculation (DPI). Double-positive suppressed a greater degree either single positive subpopulation, but similar results not observed PRRSV. These suggested abundant might atrophy
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sci-hub.se 参考文章(26)
E J Snijder, J J Meulenberg, The molecular biology of arteriviruses Journal of General Virology. ,vol. 79, pp. 961- 979 ,(1998) , 10.1099/0022-1317-79-5-961
Richard Aspinall, Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. Journal of Immunology. ,vol. 158, pp. 3037- 3045 ,(1997)
Wen-hai Feng, MB Tompkins, Jin-Sheng Xu, TT Brown, SM Laster, He-xiao Zhang, MB McCaw, None, Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus. Virology. ,vol. 302, pp. 363- 372 ,(2002) , 10.1006/VIRO.2002.1650
Guang-Zhi Tong, Yan-Jun Zhou, Xiao-Fang Hao, Zhi-Jun Tian, Tong-Qing An, Hua-Ji Qiu, Highly pathogenic porcine reproductive and respiratory syndrome, China. Emerging Infectious Diseases. ,vol. 13, pp. 1434- 1436 ,(2007) , 10.3201/EID1309.070399
J.M.A. Pol, J.E. van Dijk, G. Wensvoort, C. Terpstra, Pathological, ultrastructural, and immunohistochemical changes caused by Lelystad virus in experimentally induced infections of mystery swine disease (synonym: porcine epidemic abortion and respiratory syndrome (PEARS)). Veterinary Quarterly. ,vol. 13, pp. 137- 143 ,(1991) , 10.1080/01652176.1991.9694298
Gang Wang, Tengfei Song, Ying Yu, Yonggang Liu, Wenda Shi, Shujie Wang, Fulong Rong, Jianguo Dong, He Liu, Xuehui Cai, En-Min Zhou, Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Veterinary Immunology and Immunopathology. ,vol. 142, pp. 170- 178 ,(2011) , 10.1016/J.VETIMM.2011.05.004
L. Galina, C. Pijoan, M. Sitjar, W. Christianson, K. Rossow, J. Collins, Interaction between Streptococcus suis serotype 2 and porcine reproductive and respiratory syndrome virus in specific pathogen-free piglets. Veterinary Record. ,vol. 134, pp. 60- 64 ,(1994) , 10.1136/VR.134.3.60
G. Wensvoort, C. Terpstra, J.M.A. Pol, E.A. ter Laak, M. Bloemraad, E.P. de Kluyver, C. Kragten, L. van Buiten, A. den Besten, F. Wagenaar, J.M. Broekhuijsen, P.L.J.M. Moonen, T. Zetstra, E.A de Boer, H.J. Tibben, M.F. de Jong, P. van ‘t Veld, G.J.R. Greenland, J.A. van Gennep, M.Th. Voets, J.H.M. Verheijden, J. Braamskamp, Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Veterinary Quarterly. ,vol. 13, pp. 121- 130 ,(1991) , 10.1080/01652176.1991.9694296
Hua-Ji Qiu, Zhi-Jun Tian, Guang-Zhi Tong, Yan-Jun Zhou, Jian-Qiang Ni, Yu-Zi Luo, Xue-Hui Cai, Protective immunity induced by a recombinant pseudorabies virus expressing the GP5 of porcine reproductive and respiratory syndrome virus in piglets. Veterinary Immunology and Immunopathology. ,vol. 106, pp. 309- 319 ,(2005) , 10.1016/J.VETIMM.2005.03.008
C. Choi, C. Chae, Expression of tumour necrosis factor-α is associated with apoptosis in lungs of pigs experimentally infected with porcine reproductive and respiratory syndrome virus Research in Veterinary Science. ,vol. 72, pp. 45- 49 ,(2002) , 10.1053/RVSC.2001.0519