Clinical assessment of clonidine in the treatment of new-onset rapid atrial fibrillation: a prospective, randomized clinical trial.

作者: Christopher S. Simpson , William A. Ghali , Anthony J. Sanfilippo , Sabine Moritz , Hoshiar Abdollah

DOI: 10.1067/MHJ.2001.116761

关键词:

摘要: Abstract Purpose The role of digoxin and verapamil in the control ventricular response rapid atrial fibrillation is well established. This study investigates how clonidine compares with these standard therapies rate for new-onset fibrillation. We set out to test hypothesis that effectively reduces heart patients Subjects Methods Forty were seen emergency department (≤24 hours' duration), stable, Eligible randomized receive either clonidine, digoxin, or verapamil. Changes blood pressure over 6 hours, as frequency conversion sinus rhythm recorded analyzed. Results mean reduction hours was 44.4 beats/min (95% confidence interval [CI] 28.4-60.4 beats/min) group, 52.1 CI 40.8-63.4 41.8 22.5-61.0 group. Analysis variance changes 3 groups after not significant ( P =.55). At 7 12 patients, 8 15 13 remained =.962 on χ 2 ). Conclusion Clonidine controls an efficacy comparable agents. (Am Heart J 2001;142:e3.)

参考文章(15)
Douglas P. Zipes, José Jalife, Gordon Kenneth Moe, Cardiac electrophysiology and arrhythmias Grune & Stratton. ,(1985)
Clonidine for patients with rapid atrial fibrillation. Annals of Internal Medicine. ,vol. 116, pp. 388- 390 ,(1992) , 10.7326/0003-4819-116-5-388
Cynthia A. Sanoski, Jerry L. Bauman, Bradley G. Phillips, Vicki L. Just, Ashesh J. Gandhi, Comparison of intravenous diltiazem and verapamil for the acute treatment of atrial fibrillation and atrial flutter. Pharmacotherapy. ,vol. 17, pp. 1238- 1245 ,(1997) , 10.1002/J.1875-9114.1997.TB03087.X
Kenneth A. Ellenbogen, Virgil C. Dias, Vance J. Plumb, J.Thomas Heywood, David M. Mirvis, A placebo-controlled trial of continuous intravenous diltiazem infusion for 24-hour heart rate control during atrial fibrillation and atrial flutter: A multicenter study Journal of the American College of Cardiology. ,vol. 18, pp. 891- 897 ,(1991) , 10.1016/0735-1097(91)90743-S
Lorelei J. Repique, Sailesh N. Shah, Gary E. Marais, Atrial fibrillation 1992. Management strategies in flux. Chest. ,vol. 101, pp. 1095- 1103 ,(1992) , 10.1378/CHEST.101.4.1095
Kenneth A. Ellenbogen, Virgil C. Dias, Frank P. Cardello, William E. Strauss, Charles A. Simonton, Scott J. Pollak, Mark A. Wood, Bruce S. Stambler, Safety and efficacy of intravenousdiltiazem in atrial fibrillation or atrial flutter American Journal of Cardiology. ,vol. 75, pp. 45- 49 ,(1995) , 10.1016/S0002-9149(99)80525-6
Joan W. Flacke, Byron C. Bloor, Werner E. Flacke, Dorming Wong, Stephen Dazza, Stanley W. Stead, Hillel Laks, Reduced narcotic requirement by clonidine with improved hemodynamic and adrenergic stability in patients undergoing coronary bypass surgery. Anesthesiology. ,vol. 67, pp. 11- 19 ,(1987) , 10.1097/00000542-198707000-00003
RODNEY H. FALK, Digoxin for Converting Recent-Onset Atrial Fibrillation to Sinus Rhythm Annals of Internal Medicine. ,vol. 106, pp. 503- 506 ,(1987) , 10.7326/0003-4819-106-4-503