Hyperbranched polycarbonate-based multimolecular micelle with enhanced stability and loading efficiency.
作者： Wei Su , Xiao-hua Luo , Hua-fen Wang , Lei Li , Jun Feng
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摘要: We herein develop a facile catalyst-free method to prepare hyperbranched hydroxyl-enriched aliphatic polycarbonate according SCROP strategy. PEG-attached multiarm copolymer HEHDO-star-mPEG was further designed. It found that can self-assemble into supramolecular multimolecular micelles in water. micelle showed excellent stability with respect micellar size upon dilution, and displayed good cell-biocompatibility. An anticancer drug of doxorubicin hydrogen-bonding functionality incorporated obtained establish delivery system model. A high drug-loading content as well sustained release pattern for based achieved.
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