Lifelong exposure to dietary isoflavones reduces risk of obesity in ovariectomized Wistar rats.
作者： Anne Kurrat , Tina Blei , Felix M. Kluxen , Dennis R. Mueller , Marion Piechotta
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摘要: Scope Traditional Asian diet rich in soy isoflavones (ISOs) is discussed to be linked a lower obesity prevalence. In lifelong and short-term exposure scenarios we investigated effects of an ISO-rich on the body composition development female rats. Methods results Female Wistar rats grew up ISO-free or control (CON ISO: 467 mg/kg diet). Starting postnatal day 83, ovariectomized intact animals received high calorie Western (WD) absence presence ISO (WD 431 diet) for 12 weeks induce maintained respective (CON). One group starting after ovariectomy mimics postmenopausal women. Lifelong but not resulted reduced weight, visceral fat mass, serum leptin, smaller adipocytes. decreased hepatic SREBP-1c, ACC, FAS, PPARγ mRNA expression nonobese animals. Moreover, skeletal muscle which was antagonized by both exposure. Conclusion Our results indicate that intake reduces risk develop obesity. Furthermore, may antagonize loss mass induced ovariectomy.
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