c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans.

摘要: The c-ets1 proteins are transcriptional activators expressed within endothelial cells during blood vessel development in chick embryos. authors show by situ hybridization that is transcribed the endothelia angiogenesis human embryos, granulation tissue, and especially tumor vascularization. mRNAs were also detected fibrocytes of stroma spindle Kaposi's sarcomas, regarded as origin. It has been shown c-ets activate transcription through a PEA3 motif plays role stimulation urokinase-type plasminogen-activator (u-PA), stromelysin collagenase genes. demonstrate vitro angiogenic factor TNF alpha increases transiently amount both u-PA mRNA confluent umbilical vein cells. Therefore, suggest might regulate genes coding for matrix-degrading proteases, which necessary invasion.