Binding of chlorpyrifos and cypermethrin to blood proteins
作者： Yong Cui , Jiangfeng Guo , Bujin Xu , Ziyuan Chen
DOI: 10.1016/J.PESTBP.2005.11.004
关键词:
摘要: Abstract The features of two insecticides (chlorpyrifos and cypermethrin) binding to blood proteins, bovine serum albumin (BSA), hemoglobin (BHb), were investigated via the fluorescence method. results revealed that both caused quenching BSA enhancement BHb. A new parameter (FE), i.e., intensity when adequate insecticide was added, introduced obtain association constant (KA) number sites (n). KA n chlorpyrifos cypermethrin 2.99 × 105 5.22 × 105 L mol−1, 1.25 0.78, respectively. BHb 2.94 × 104 2.48 × 104 L mol−1, 1.75 2.19, In conclusion, could bind BHb, significantly stronger than These affect distribution, metabolism, excretion insecticides.
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