Highly efficient chemoenzymatic syntheses of trans-2-aminocyclopentanol derivatives
作者： Javier González-Sabín , Francisco Morís-Varas , Carmen Peña , Francisca Rebolledo , Vicente Gotor
DOI: 10.1016/J.MOLCATB.2009.01.006
关键词:
摘要: Abstract A novel and efficient chemoenzymatic protocol for the preparation of both enantiomers trans -2-aminocyclopentanol is described. The key steps this strategy are synthesis subsequent Burkholderia cepacia lipase-catalyzed resolution racemic precursor -2-(diallylamino)cyclopentanol. In addition, a variety diversely substituted derivatives prepared from enantiopure compounds isolated in biotransformation by means simple protection–deprotection reactions.
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