Post-Ugi Cyclization for the Construction of Diverse Heterocyclic Compounds: Recent Updates.
作者： Jitender Bariwal , Rupinder Kaur , Leonid G. Voskressensky , Erik V. Van der Eycken
关键词:
摘要: Multicomponent reactions (MCRs) have proved as a valuable tool for organic and medicinal chemist because of their ability to introduce large degree chemical diversity in the product single step with high atom economy. One dominant MCRs is Ugi reaction, which involves condensation an aldehyde (or ketone), amine, isonitrile carboxylic acid afford -acylamino carboxamide adduct. The desired Ugi-adducts may be constructed by careful selection building blocks, opening door post-Ugi modifications. Such transformations represent extremely powerful synthetic methods construction diverse heterocycles. In recent years, such expanded rapidly, giving access various heterocyclic systems. This review outlines developments achieved past few highlighting modifications performed sequential or domino fashion, emphasis on major concepts, applications derived products well critical mechanistic aspects.
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