Ontogeny of the porcine insulin-like growth factor system
作者： C.Y. Lee , C.S. Chung , F.A. Simmen
DOI: 10.1016/0303-7207(93)90141-6
关键词:
摘要: The developmental expression of the individual components insulin-like growth factor (IGF) system in pigs was examined. Serum IGF-I and IGF-binding protein-3 (IGFBP-3) levels were low during fetal life increased postnatal development. Levels mRNAs encoding these proteins not greater for liver than nonhepatic tissues (skeletal muscle, lung, kidney) did increase period, whereas hepatic hormone (GH) receptor mRNA postnatally. IGF-II exceeded at all stages examined both exhibited increases. abundance, contrast, high with exception lung declined perinatal transition. Hepatic IGFBP-2 serum latter half gestation then muscle type I IGF receptors corresponding also decreases. discordance changes abundance period does support concept that is primary endocrine source IGFs young pig. increases may reflect decreased plasma clearance rates peptides which be related to transition IGFBP from IGFBP-3 blood reduced tissue receptors.
elsevier.com
sci-hub.se 参考文章(41)
A L Brown, L Chiariotti, C C Orlowski, T Mehlman, W H Burgess, E J Ackerman, C B Bruni, M M Rechler, Nucleotide Sequence and Expression of a cDNA Clone Encoding a Fetal Rat Binding Protein for Insulin-like Growth Factors Journal of Biological Chemistry. ,vol. 264, pp. 5148- 5154 ,(1989) , 10.1016/S0021-9258(18)83711-5
J Massagué, M P Czech, The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. Journal of Biological Chemistry. ,vol. 257, pp. 5038- 5045 ,(1982) , 10.1016/S0021-9258(18)34631-3
P K Lund, B M Moats-Staats, M A Hynes, J G Simmons, M Jansen, A J D'Ercole, J J Van Wyk, Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues. Journal of Biological Chemistry. ,vol. 261, pp. 14539- 14544 ,(1986) , 10.1016/S0021-9258(18)66903-0
M M Sklar, W Kiess, C L Thomas, S P Nissley, Developmental expression of the tissue insulin-like growth factor II/mannose 6-phosphate receptor in the rat. Measurement by quantitative immunoblotting. Journal of Biological Chemistry. ,vol. 264, pp. 16733- 16738 ,(1989) , 10.1016/S0021-9258(19)84766-X
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Paul HOSSENLOPP, Danielle SEURIN, Berta SEGOVIA, Ghyslaine PORTOLAN, Michel BINOUX, Heterogeneity of insulin-like growth factor binding proteins between structure and affinity FEBS Journal. ,vol. 170, pp. 133- 142 ,(1987) , 10.1111/J.1432-1033.1987.TB13677.X
A. Ullrich, A. Gray, A.W. Tam, T. Yang-Feng, M. Tsubokawa, C. Collins, W. Henzel, T. Le Bon, S. Kathuria, E. Chen, Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. The EMBO Journal. ,vol. 5, pp. 2503- 2512 ,(1986) , 10.1002/J.1460-2075.1986.TB04528.X
J. Zapf, C.H. Schmid, E.R. Froesch, 1 Biological and immunological properties of insulin-like growth factors (IGF) I and II Clinics in Endocrinology and Metabolism. ,vol. 13, pp. 3- 30 ,(1984) , 10.1016/S0300-595X(84)80006-7
B. H. Breier, P. D. Gluckman, H. T. Blair, S. N. McCutcheon, Somatotrophic receptors in hepatic tissue of the developing male pig. Journal of Endocrinology. ,vol. 123, pp. 25- 31 ,(1989) , 10.1677/JOE.0.1230025
THEODORE ALEXANDRIDES, ALAN C. MOSES, ROBERT J. SMITH, Developmental Expression of Receptors for Insulin, Insulin-like Growth Factor I (IGF-I), and IGF-II in Rat Skeletal Muscle* Endocrinology. ,vol. 124, pp. 1064- 1076 ,(1989) , 10.1210/ENDO-124-2-1064