Multiple dosing of prostaglandin F2 alpha or epinephrine on cynomolgus monkey eyes. II. Slit-lamp biomicroscopy, aqueous humor analysis, and fluorescein angiography.

摘要: Prostaglandin (PG) F2 alpha (250 micrograms in 50 microliters saline) or epinephrine 2% solution (50 microliters) was topically applied twice daily for 2 weeks to one eye of six cynomolgus monkeys each agent. Contralateral control eyes received their respective vehicles. A trace aqueous humor flare response occurred some PGF2 alpha-treated eyes, which reached significance (P less than 0.05) only when observed 4 hr after the first seventh dose. No significant anterior chamber cellular treated as compared eyes. Slit-lamp biomicroscopic evaluation cornea, iris, and lens showed no differences throughout study. Aqueous samples were obtained from all ninth consecutive Soluble protein concentration significantly 0.01) greater (1.22 +/- 0.30 mg/ml) (0.56 0.17 epinephrine-treated (0.59 0.18 mg/ml). Microscopic examination sediments centrifugation revealed cells experimental samples. Both PGE2 levels 0.025) a trend towards being Neither cystoid macular edema nor other retinal abnormalities evident by fluorescein angiography any during second week treatment. Multiple dosing monkey does not appear produce clinically adverse effects either posterior segment would contraindicate its use multiple-dose clinical trial glaucoma patients.