Efficacy and safety of sildenafil in Asian males with erectile dysfunction and cardiovascular risk.

摘要: Objective: Assess the effectiveness of sildenafil in Asian males with erectile dysfunction (ED) and one or more of co-morbidities, mild-to-moderate hypertension, dyslipidemia, diabetes. Material Method: A six-week, double-blind, randomized, placebo-controlled, multicenter study was carried out Thailand, Malaysia Singapore One hundred fifty five male subjects were randomized (2:1) to (n = 104) placebo 51). Sildenafil was started at 50mg increased (100 mg) or decreased (25mg) week 2 if necessary. Results: On primary efficacy endpoint, sildenafil-treated had significantly better scores on the International Index Erectile Function (IIEF) questions 3 4 than (p < 0.001, both questions). When accumulated into IIEF domains, all domains significant favor sildenafil. In addition, sildenafil-treated more satisfied treatment a higher intercourse success rate. The majority adverse events mild severity; most commonly reported treatment-related were dizziness (7.7%) tinnitus (2.9%). Conclusion: (25, 50, 100 found be an effective, safe, well-tolerated for ED present population Thai, Malaysian, Singaporean who also increased cardiovascular risk Keywords: Sildenafil, dysfunction, Randomized controlled trial,Cardiovascular risk, Diabetes mellitus