Quality of laboratory studies assessing effects of Bt -proteins on non-target organisms: minimal criteria for acceptability

摘要: The potential risks that genetically modified plants may pose to non-target organisms and the ecosystem services they contribute are assessed as part of pre-market risk assessments. This paper reviews early tier studies testing hypothesis whether exposure plant-produced Cry34/35Ab1 proteins a result cultivation maize 59122 is harmful valued organisms, in particular Arthropoda Annelida. available were for their scientific quality by considering set criteria determining relevance reliability. As case-study, this exercise revealed when not all met, weighing robustness study its assessment obvious. Applying worst-case expected environmental concentration bioactive toxins equivalent present transgenic crop, confirming test species substance, use negative control identified minimum be met guarantee sufficiently reliable data. stresses importance conducting meeting certain standards minimises probability erroneous or inconclusive results increases confidence adds certainty conclusions drawn.