Inhibition of Erythema and Local Hyperthermia

摘要: Each of the four cardinal signs inflammation (rubor, calor, tumor, dolor), as recorded by Celsus in first century A.D., has been used pharmacologists to establish methods for detection and definition anti-inflammatory substances (Swingle, 1974). The inhibition an induced oedema, usually paw rat, preferred method (Whitehouse, 1965; Winter, 1966; Swingle, Inhibition appearance erythema guinea pigs after exposure depilated skin ultraviolet (UV) ligth (Wilhelmi, 1949, 1950; Winder et al., 1958) also a popular method, particularly drugs which may properly be classified anti-inflammatory/analgesic/antipyretic. Procedures utilizing human assessment antierythemic activity include UV irradiation that topical application tetrahydrofurfuryl nicotinate (THFN) (Truelove Dthieu, 1959; Adams Cobb, 1963). development availability thermometers capable recording temperature accurately rapidly have led use this parameter some investigators evaluate inflammatory effects.