The Role of TOR Signaling in Aging
作者： Matt Kaeberlein , Lara S. Shamieh
DOI: 10.1007/978-90-481-3465-6_7
关键词:
摘要: The target of rapamycin (TOR) kinase defines a highly conserved nutrient-response pathway that is known to modulate longevity in invertebrate organisms. Multiple mutations this reduce TOR signaling have been reported increase life span different organisms, as has pharmacological inhibition TOR. TOR-regulated processes are also play role control, including autophagy, mRNA translation initiation, and mitochondrial metabolism. interacts with insulin/IGF-1 via Akt maps genetically the same dietary restriction. Studies underway determine whether sufficient mammals. TOR-inhibitors clinically useful humans may prove beneficial against multiple age-associated diseases.
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