Chemical Composition, Antimicrobial, Cytotoxic and Antiplasmodial Activities of Three Sponges from Buton Islands, Indonesia
作者： Masteria Yunovilsa Putra , Tri Aryono Hadi
DOI: 10.14710/IK.IJMS.22.3.147-154
关键词:
摘要: GC-MS analysis of the crude extracts three different species Indonesian marine sponges has been carried out for identification bioactive compounds. The from Haliclona (Gellius) sp., Lamellodysidea herbacea, and Spheciospongia inconstan s revealed presence 23, 21, 19 various compounds, respectively mainly sterols fatty acids. All sponge evaluated antimicrobial activities, cytotoxicity using brine shrimp lethality bioassay heme polymerization inhibitory activity assay antiplasmodial activity. In this study, all showed activities against at leastone test strains. Among them, extract herbacea displayed two Gram-positive bacteria (S. aureus B. subtilis) Gram-negative V. cholerae, with inhibition zones 10.3, 9.2 9.5 mm, respectively. (Gellius ) sp. , significant fungal pathogen C. albicans. ability to inhibit indicating an anti-Plasmodium function also potent cytotoxic Artemia Keywords : analysis, antimicrobial, sponges,bioactive
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