Biological principles for multimodal therapy approaches

摘要: Cancer development and progression has been associated with numerous genetic events in tumor cells. Germline mutations of caretaker gatekeeper genes are responsible for hereditary cancer syndromes. Exogenous factors conjunction functional germline variants a variety may contribute to initiation sporadic malignant disease. Furthermore, pathways neoplasia require somatic the developing tumor. Acquired or inherited instability permits stepwise progression. The most fearsome aspect is dissemination cells draining lymph nodes primary distant organs, which limits effectiveness surgical therapy. Cellular heterogeneity neoplasms important implications chemotherapy radiotherapy. An increasing understanding molecular biology tumors prerequisite improved prediction, prevention therapy