The differential effects of atorvastatin co-administered with ampicillin on the bacterial growth and biofilm formation of Staphylococcus aureus

摘要: Abstract Objectives In the past years, there have been increases in S. aureus infections, intensifying demand for new and effective drugs. Apparently, old drugs such as statins shown unexpected pleiotropic effects, may be exploited or repurposed to meet demands on antimicrobial therapy. this study, antibacterial activity of atorvastatin possible interactions with ampicillin were evaluated by determining minimum inhibitory concentration (MIC), synergism, biofilm inhibition these against ATCC 29213. Methods ampicillin, alone combination, tested property using MIC assay, synergism via checkerboard microdilution assay. Both then formation check its relevance sessile bacterial states. Results Atorvastatin did not display anti-bacterial consistent previous reports, but synergistically inhibited planktonic growth lowering 8-fold. Further, abrogated 48h-grown − implicative role chronic infection, lost when co-administered a ratio 1:1. Conclusion These suggest that fact targeting common pathway integral formation, warrants further verification mechanisms involved well identification novel enzyme off-targets could potentially impact treatment infections.