SPONTANEOUS REMISSION IN ACUTE LEUKEMIA

摘要: Wide interest has been aroused by a recent report that temporary remissions of acute leukemia have produced in children with the aid so-called folic acid antagonist. Despite its toxicity, Farber, Diamond, Mercer, Sylvester and Wolff 1 found administration aminopterin® (4-aminopteroyl glutamic acid) produces, majority patients treated, dramatic clinical improvement together striking alteration toward normal peripheral blood bone marrow pictures. Comparable appreciable duration never before numerous therapeutic agents. On other hand, sporadically, observed to occur without apparent relationship therapy. Authenticated instances spontaneous remission now seem worthy review because they constitute control group which may be compared examples drug-induced remission. Ten such cases described since 1931, an additional example unusually long (twenty-one months) is herein