Duration of second complete remission compared with first complete remission in patients with acute myeloid leukemia

作者: S Lee , , MS Tallman , MM Oken , PA Cassileth

DOI: 10.1038/SJ.LEU.2401853

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摘要: The prognosis for patients with acute myeloid leukemia in first relapse is generally poor. ability to induce a second complete remission (CR) the same chemotherapy used initial induction therapy limited. Remission inversion rate, defined as achieving longer CR than response standard relapse, important assessing studies of novel or immunologic treatment strategies relapsed disease. One hundred and twenty-four entered on two Eastern Cooperative Oncology Group (ECOG) AML were analyzed determine rate. Twenty-two 124 (18%; 95% confidence interval 12-26%) experienced duration by at least 2 months. Inversion thus not rare event. frequency reported here establishes baseline upon which future disease need be defined.

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