Anti-leukemic activity of valproic acid and imatinib mesylate on human Ph+ ALL and CML cells in vitro
作者： Brigitte Kircher , Petra Schumacher , Andreas Petzer , Elisabeth Hoflehner , Margot Haun
DOI: 10.1111/J.1600-0609.2009.01242.X
关键词:
摘要: The armamentarium of anti-leukemic drugs has increased substantially since activities were recently found for a variety non-classical cytostatic drugs, among them the histone deacetylase (HDAC) inhibitor valproic acid (VPA). This study investigated effect VPA on proliferation and apoptosis human Philadelphia chromosome-positive (Ph+) acute lymphatic (ALL) chronic myeloid leukemia (CML) cells colony formation chronic-phase CML progenitor cells. Strong anti-proliferative pro-apoptotic effects observed ALL cell lines at concentrations achievable in vivo. These most pronounced as well primary Notably, revealed enhanced activity with imatinib mesylate, nilotinib, farnesyl transferase SCH66336, interferon-alpha cytosine arabinoside. inhibited growth colony-forming from 12 Ph+ patients but also those normal healthy controls dose-dependent fashion. HDAC-inhibiting was confirmed In conclusion, VPA, whether alone or combination other compounds, exerts significant
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