Reduction of vitamin K2 concentrations in human liver associated with the use of broad spectrum antimicrobials.

摘要: It is unclear whether menaquinones produced by the intestinal microflora play any role in human nutrition. Reports of coagulopathy due to vitamin K deficiency occurring patients receiving broad spectrum antibiotics indirectly suggest that K2 gut may be utilized host. We analyzed K1 (phylloquinone) and (menaquinone) content a convenience sample 22 post-mortem liver samples, including 9 individuals who had been antimicrobials prior death 13 victims sudden, unexpected deaths. There were no significant differences mean (+/- SEM) phylloquinone between 2 groups [21.9 15.5) vs. 16.0 9.3) pmol/g wet weight (excluding those received supplemental K1)] but there was difference (p < 0.05) total menaquinone (MK) content, 70.0 23.3) 423.1 141) groups. These findings an association receipt reduction hepatic concentration, lending support hypothesis responsible for their production leads reduced stores this form vitamin.