Constraints to Articular Cartilage Regeneration

摘要: The glassy translucent material found at the ends of bones, within synovial joints, is termed articular cartilage. While healthy, it provides a low-friction bearing surface, preventing bone-to-bone contact, and to an extent, absorb shock during vigorous activities. However, when damaged could lead pain, deformity reduced mobility; social impact which, entails high costs in terms therapeutic treatments loss income. present chapter reviews common knowledge constraints cartilage regeneration; namely structure, composition major diseases. first three sections detail constituents tissue their structural organisation; tissues mechanical properties, with brief description how these features change unhealthy cartilage; be or disease. In second section, both clinical academic approaches are pooled together, review current strategies restoring health joints diseased final section highlights fact that progression disease affects not only cartilage, but its underlying bone. implications subchondral bone propagation degeneration discussed, finally, considerations defect healing.