Accelerated Aging in Schizophrenia Patients: The Potential Role of Oxidative Stress

摘要: Several lines of evidence suggest that schizophrenia, a severe mental illness characterized by delusions, hallucinations and thought disorder is associated with accelerated aging. The free radical (oxidative stress) theory aging assumes occurs as result damage to cell constituents connective tissues radicals arising from oxygen-associated reactions. Schizophrenia has been oxidative stress chronic inflammation, both which also appear reciprocally induce each other in positive feedback manner. buildup damaged macromolecules due increased failure protein repair maintenance systems an indicator at the cellular organismal level. When compared age-matched healthy controls, schizophrenia patients have higher levels markers such carbonyls, products lipid peroxidation DNA hydroxylation. Potential confounders antipsychotic medication, smoking, socio-economic status unhealthy lifestyle make it impossible solely attribute earlier onset aging-related changes or having diagnosis schizophrenia. Regardless whether can be attributed factors available support stress-induced may play role phenomenon presumed