DNA interaction and anticancer evaluation of new zinc(II), ruthenium(II), rhodium(III), palladium(II), silver(I) and platinum(II) complexes based on kojic acid; X-ray crystal structure of [Ag(ka)(PPh3)]·H2O
作者： Neveen A. Annan , Ian S. Butler , Hatem M. Titi , Yahia El-Lazeik , Bertrand J. Jean-Claude
DOI: 10.1016/J.ICA.2018.12.031
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摘要: Abstract The syntheses of some new zinc(II), palladium(II), platinum(II), ruthenium(II), rhodium(III) and silver(I) complexes kojic acid (Hka) in both the absence presence N,N- (2,2′-bipyridyl) P- (triphenylphosphine) ligands are reported. X-ray crystal structure mixed-ligand complex, [Ag(ka)(PPh3)], has been determined. It crystallized a monoclinic lattice with space group symmetry P21/n. molecular structures discussed on basis their IR, NMR (1H, 13C, 31P), UV-Vis, EI maldi-mass spectra, elemental analyses, molar conductivities TGA behaviour. Kojic coordinates to central metal ions mono-negative bidentate fashion through carbonyl O- deprotonated ring hydroxy-O atoms. vitro anticancer activities several have examined against human ovarian cancer (VC-8-BRCA & VC-8) cell lines. IC50 values for growth proliferation [Ag(ka)(PPh3)] 8.80 8.87 μM, respectively. corresponding cisplatin 9.12 10.07 μM. DNA-binding properties studied using UV-vis spectroscopy. results indicate that may undergo intercalative CT-DNA binding view hypochromism. constants (Kb) show low-to-moderate abilities, which result from steric hindrance around primary chelate or bulky secondary (bpy, PPh3) moieties.
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