Contribution of autophagy to antiviral immunity.

摘要: Although identified in the 1960's, interest autophagy has significantly increased past decade with notable research efforts oriented at understanding as to how this multi-protein complex operates and is regulated. Autophagy commonly defined a "self-eating" process evolved by eukaryotic cells recycle senescent organelles expired proteins, which during cellular stress responses. In addition, can also play important roles human diseases, such cancer, neurodegenerative autoimmune disorders. Furthermore, novel findings suggest that contributes host defense against microbial infections. article, we review role of macroautophagy antiviral immune responses discuss molecular mechanisms viral pathogens evade process. A for an effector mechanism used both, innate adaptive immunity discussed.