The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis

摘要: Background. There have been inconsistent reports on the prevalence and pathogenicity of anti-Aquaporin 4 (AQP4) in patients presented with idiopathic inflammatory demyelinating diseases (IIDDs). Objective. To estimate anti-AQP4 antibody IIDDs to University Malaya Medical Centre terms patients’ clinical radiological presentations prognoses. Methods. Retrospective data review from 2005 2015. Patients were classified into classical multiple sclerosis (CMS), opticospinal (OS) presentation, optic neuritis (ON), transverse myelitis (TM), brainstem syndrome (BS), tumefactive MS. Anti-Aquaporin was tested using Indirect Immunofluorescence Test (IIFT) cell-based assay. Statistical analysis done SPSS version 20. Results. Anti-AQP4 detected 53% IIDDs. CMS more common seronegative group, 27/47 (57.45%; ). Conversely, OS involvement seropositive 26/53 (49.06%; Longitudinally extensive spinal cord lesions (LESCLs) MRI also 29/40 (72.50%; Only 2/40 (5.00%) had evidence patchy or short-segment AQP4-positive group (). The relapse rate Expanded Disability Status Scale (EDSS) higher (5.43 versus 3.17, ; 4.07 2.51, , resp.). Typical that defined NMO seen patients, but a lower frequency. Conclusion. Our cohort seropositivity as compared those Western countries. This associated typical presentation LESCLs MRI, relapse, EDSS.