Novel nanostructured biodegradable polymer matrices fabricated by phase separation techniques for tissue regeneration
作者： S.-h. Hsu , S. Huang , Y.-C. Wang , Y.-C. Kuo
DOI: 10.1016/J.ACTBIO.2013.02.012
关键词:
摘要: Abstract Biomimetic nanostructures have a wide range of applications. In particular, biodegradable polymer that mimic the subtleties extracellular matrix may provide favorable cell interactions. this study, co-solvent system was developed to configure thermodynamically metastable solution, from which novel nanostructured matrices subsequently formed via wet phase separation (quaternary) or combination with thermally induced separation. Three-dimensional (3D) porous were further fabricated by particle-leaching (100–300 μm glucose). The new generate reproducible variety polymers such as poly( d , l -lactide) (PLA), poly(e-caprolactone) (PCL) and PCL-based polyurethane. vitro culture experiments performed mouse pre-osteoblasts (MC3T3-E1) human bone marrow-derived mesenchymal stem cells (hBM-MSC) evaluate osteoinductive potential PLA nanostructures. results showed nanofibrous (
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