Immune Priming of the Tumor Microenvironment by Radiation.
作者： Wen Jiang , Charles K. Chan , Irving L. Weissman , Betty Y.S. Kim , Stephen M. Hahn
DOI: 10.1016/J.TRECAN.2016.09.007
关键词:
摘要: Ionizing irradiation can induce a multitude of alterations within the tumor microenvironment. Unlike targeted therapies, radiation delivered to bed prompt phenotypic changes in both normal stromal and cancer cells, leading molecular physiological These environmental modulations directly influence degree immunogenicity microenvironment may ultimately affect responsiveness immunotherapies. Here we review preclinical evidence for microenvironment-mediated immune suppression how modulate properties tumor. We then discuss therapeutic opportunities combining with agents enhance this represents potential exciting strategy complement immunotherapies including checkpoint blockers treatment.
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