Vitamin D as a Neurosteroid Affecting the Developing and Adult Brain

作者: Natalie J. Groves , John J. McGrath , Thomas H.J. Burne

DOI: 10.1146/ANNUREV-NUTR-071813-105557

关键词:

摘要: Vitamin D deficiency is prevalent throughout the world, and growing evidence supports a requirement for optimal vitamin levels healthy developing adult brain. has important roles in proliferation differentiation, calcium signaling within brain, neurotrophic neuroprotective actions; it may also alter neurotransmission synaptic plasticity. Recent experimental studies highlight impact that on brain function health disease. In addition, results from recent animal suggest during adulthood exacerbate underlying disorders and/or worsen recovery stressors. An increasing number of epidemiological indicate associated with wide range neuropsychiatric neurodegenerative diseases. supplementation readily available affordable, this review highlights need further research.

参考文章(208)
S. Korsching, G. Auburger, R. Heumann, J. Scott, H. Thoenen, Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. The EMBO Journal. ,vol. 4, pp. 1389- 1393 ,(1985) , 10.1002/J.1460-2075.1985.TB03791.X
Soroush Seifirad, Arash Dehghan, Mohammad Ali Seifrabie, Mehrdokht Mazdeh, Niloofar Kazemi, Hamidreza Abbasi, Comparison of vitamin D3 serum levels in new diagnosed patients with multiple sclerosis versus their healthy relatives. Acta medica Iranica. ,vol. 51, pp. 289- 292 ,(2013)
Erdinç Dursun, Duygu Gezen-Ak, Selma Yilmazer, A new mechanism for amyloid-β induction of iNOS: vitamin D-VDR pathway disruption. Journal of Alzheimer's Disease. ,vol. 36, pp. 459- 474 ,(2013) , 10.3233/JAD-130416
Elham Nikravesh, Ghazal Jalilzadeh, Hossein Pakdaman, Nazanin Mirabi, Seyed-Mohammad Fereshtehnejad, Saeed Shahbeigi, Vitamin d3 concentration correlates with the severity of multiple sclerosis. International Journal of Preventive Medicine. ,vol. 4, pp. 585- 591 ,(2013)
John A. Eisman, Peter J. M. Tutton, David H. Barkla, Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3. Cancer Research. ,vol. 47, pp. 21- 25 ,(1987)
Cedric Annweiler, David J. Llewellyn, Olivier Beauchet, Low Serum Vitamin D Concentrations in Alzheimer's Disease: A Systematic Review and Meta-Analysis Journal of Alzheimer's Disease. ,vol. 33, pp. 659- 674 ,(2013) , 10.3233/JAD-2012-121432
Marie-France Nissou, Jacques Brocard, Michèle El Atifi, Audrey Guttin, Annie Andrieux, François Berger, Jean-Paul Issartel, Didier Wion, The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases Journal of Alzheimer's Disease. ,vol. 35, pp. 553- 564 ,(2013) , 10.3233/JAD-122005
Don M. Gash, Zhiming Zhang, Greg Gerhardt, Neuroprotective and neurorestorative properties of GDNF. Annals of Neurology. ,vol. 44, ,(1998) , 10.1002/ANA.410440718
Robin M. Daly, Claudia Gagnon, Zhong X. Lu, Dianna J. Magliano, David W. Dunstan, Ken A. Sikaris, Paul Z. Zimmet, Peter R. Ebeling, Jonathan E. Shaw, Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older : A national, population-based study Clinical Endocrinology. ,vol. 77, pp. 26- 35 ,(2012) , 10.1111/J.1365-2265.2011.04320.X