Adrenal medulla grafts produce blood-brain barrier dysfunction
作者： Jeffrey M. Rosenstein
DOI: 10.1016/0006-8993(87)91346-1
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摘要: Abstract The results of this study show that grafts adrenal medulla into the rat brain parenchyma or ventricle produced significant blood-brain barrier dysfunction. Systematically administered protein rapidly entered either grafts, surrounding tissue cerebrospinal fluid. grafted chromaffin cells avidly took up blood-borne radiolabelled amine. Thus, autonomic transplants prevented normal reconstitution after surgery and indefinitely exposed host to compounds.
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