Nanocapsules for 5-fluorouracil delivery decorated with a poly(2-ethylhexyl methacrylate-co-7-(4-trifluoromethyl)coumarin acrylamide) cross-linked wall

摘要: The first synthesis of polymer vesicles with reverse cross-linked walls from poly[2-ethylhexylmethacrylate-co-(7-(4-trifluoromethyl)coumarin acrylamide)] P(EHMA/FMCA) is reported. synthesis, carried out under UV light (λ = 350 nm), was achieved via radical photopolymerization hydrophobic compounds saturating the bilayer 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposome template. polymerization reaction coumarin moieties has a pivotal role, because chains become as result dimerization side formed polymers and, in this way, spherical capsules are obtained. Moreover, thanks to incorporation moieties, an additional bonus, nanometer-thick porous, fluorescent wall formed, avoiding use cross-linking reagents, which might deactivate encapsulated payloads. We present new paradigm release drug delivery systems combining long shelf-life ability for rapid using external factors such light. To demonstrate concept, target hydrophilic dyes (Lucifer yellow (LY), phenosafranin (PhS)) and 5-fluorouracil (5-FU)) were incorporated inside stable, hollow, polymeric nanocapsules. goal these applications depends on versatile strategy that used preparation highly emissive nanometer-sized surface functionalities optical properties diagnostic applications.