Intracytoplasmic sperm injection with testicular spermatozoa is less successful in men with nonobstructive azoospermia than in men with obstructive azoospermia

摘要: Abstract Objective To assess the efficiency of intracytoplasmic sperm injection (ICSI) using testicular spermatozoa in cases nonobstructive azoospermia. Design Retrospective case series. Setting Tertiary university-based infertility center. Patient(s) Overall, 595 couples were included. In 360 couples, man had normal spermatogenesis. 118, 85, and 32 germ-cell aplasia, maturation arrest, tubular sclerosis/atrophy, all with focal spermatogenesis present. Intervention(s) We performed 911 ICSI cycles fresh obtained after biopsies: 306 used from men azoospermia, 605 obstructive Main outcome measure(s) Fertilization, cleavage, implantation, pregnancy rates. Result(s) 2PN fertilization rate was lower group: 48.5% vs. 59.7%. There no differences vitro development or morphological quality embryos. group, a total 718 embryos transferred (262 transfers) 1,525 group (544 transfers). Both clinical implantation per cycle significantly compared 8.6% 12.5% 15.4% 24.0%, respectively. Conclusion(s) A statistically significant results