Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, double-blind, placebo-controlled trial.

摘要: The objective was to assess the safety of chloroquine (CQ) as prophylaxis against Plasmodium vivax infection during pregnancy. One thousand pregnant Karen women were enrolled in a randomized double-blind placebo-controlled trial chemoprophylaxis with (500 mg phosphate (or 300 base) weekly). Women received median (range) total dose 9500 (1500-17 500) mg. mothers actively followed from inclusion delivery and their infants until 12 months age. Chloroquine completely prevented P. episodes; 10.1% (95% CI: 7.3-14.5) placebo group experienced at least one episode malaria but no occurred CQ group. By contrast numbers falciparum episodes similar each group: 7.4% 3.7-11.1) 5.6% 3.3-7.9) groups respectively (P = 0.56). well tolerated there difference proportions reported side effects between treated except for duration palpitations sleeping disorders which more frequent those who had CQ. impact on maternal anaemia birth weight gestational age development newborns or growth neurological visual acuity 1 year is safe effective pregnancy this population. (authors)