Direct access to 2-amino-5-azidomethylfurans through palladium-catalyzed azidative cycloisomerization of homoallenyl amides
作者： Qianwen Huang , Hanliang Zheng , Shuiyou Liu , Lichun Kong , Fang Luo
DOI: 10.1039/C6OB01491G
关键词:
摘要: A room temperature, efficient, and palladium-catalyzed azidative cycloisomerization of homoallenyl amides using TMSN3 as the azidation reagent PhI(O2CCF3)2 oxidant is described, producing a variety 2-amino-5-azidomethylfurans in moderate to excellent yields. The products can be applied concise synthesis 1,2,3-triazoles via Cu-catalyzed azide–alkyne cycloaddition.
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