Anti-oxidant, Anti-inflammatory and Anti-cancer Effect of Methanol Extract of Pogostemon cablin

摘要: In the present study, substance that show anti-proliferation of cancer cells as well anti-oxidant and anti-inflammatory effect was searched. As a results, methanol extract Pogostemon cablin (P. cablin), is well-known herb for traditional medicine in Korea China treating digestive disorders, less appetite, vomiting diarrhea, inhibited growth various such A549, HepG2, MCF7 HT29 cells. Cytotoxic extraction P. ex-cellent A549 induced cell cycle arrest at G1 phase dose depend-ent manner. And it phosphorylation p38 Cdc25A reduced expression Cdc25A, Cdks, Cyclins phospho-Retinoblastoma (Rb) proteins. Therefore, seems to act through - Cdk Cyclin –Rb pathway addition, showed by DPPH free radical scavenging assay anti-inflammation in-hibition lipopolysaccharide (LPS)-induced nitric oxide (NO) RAW 264.7 dose-dependent Taken together, these results suggest may be used not only candidate materi-als anti-cancer, anti-oxidant, moreover, would possible utilized vari-ous health functional food materials.